Reaction of Bone to Disorders and Injuries

Posted on July 26, 2007. Filed under: bone, Fracture, medic, orthopaedic | Tags: bone disorder, bone reaction, medic, orthopaedic |

Four basic ways in which bone can react to abnormal conditions:

1. Local death
2. An alteration of bone deposition
3. An alteration of bone resorption
4. Mechanical failure

Reactions of living bone may be outlined as follows:

1. Altered deposition of bone

a)    Increased deposition (increased formation of matrix with normal calsification)

b)    Decreased deposition (either decreased formation of matrix or hypocalsification)

2.  Altered resorption of bone

a)    Increased resorption

b)    Decreased resorption

3. Combinations of altered deposition and resorption of bone

Examples of Reactions of Living Bone

1. Generalized Reactions as an organ

a)    Bone deposition greater than bone resorption (generalized increase in bone)

(1)  Osteopetrosis (Marble Bones)

(2)  Acromegaly

b)    Bone deposition less than bone resorption (generalized decrease in bone)

(1)  Osteoporosis (Osteopenia)

(2)  Rickets in Children and Osteomalacia in Adults

2. Localized reactions as a structure

a)    Bone doposition greater than bone resorption (Localized increase in bone)

(1)  Work Hypertrophy

(2)  Degenerative Osteoartritis

(3)  Fractures

(4)  Infection

(5)  Osteosclerotic Neoplasm

b)    Bone deposition less than bone resorption (Localized decrease in bone)

(1)  Disuse Atrophy (disuse osteoporosis)

(2)  Rheumathoid Arthritis

(3)  Infecton

(4)  Osteolytic Neoplasm

(from Salter RB, Textbook of Disorders and Injuries of the Musculoskeletal System)

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